VWF^−/− mice are protected from flow restriction–induced venous thrombosis. IVC stenosis (A-C) or stasis (D-F) in WT, VWF^+/−, and VWF^−/− mice was produced. After 48 hours, mice were killed and thrombi were harvested. Values for weight and length of the thrombi are presented in A-B (stenosis model) and D-E (stasis model). The percentage of mice with a thrombus is shown in panels C and F for stenosis and stasis models, respectively. Horizontal bars in dot plots represent median. Stenosis model: WT, n = 6; VWF^+/−, n = 10; VWF^−/−, n = 14. Stasis model: WT, n = 11; VWF^+/−, n = 10; VWF^−/−, n = 9.