Rates of change of IL-7 and CD127 receptors and growth rates of CD127⁺ and CD127⁻ T cells of CD4⁺ and CD8⁺ T-cell subsets. (A) Time profiles for the correlation between the rate of change in serum IL-7 levels and that in CD3⁺127⁺ T cells/μL (red line), and the correlation between the rate of change in serum IL-7 and that in CD3⁺127⁻ (blue line), with the dashed lines indicating the respective 95% confidence intervals. (B) Time profiles for the correlation between the rate of change in serum IL-7 with that in total CD3⁺ (black), CD4⁺ (red), and CD8⁺ (green) T cells/μL. The dashed lines represent the 95% confidence intervals. These time profiles are estimated up to 6 months, because later observations were sparse and the algorithm failed to converge. The growth rates of total (C-D), naive (E-F), CM (G-H), EM (I-J), and effector (K-L) CD4⁺ and CD8⁺ T cells after ART initiation. Median values are shown. The growth rate from M0 to M3 with intermediate data at M1 is calculated with the linear interpolation and is plotted at 1.5 months on the x-axis. P values represent the differences in the growth rate between CD127⁺ and CD127⁻ T cells. Significant P values < .01 are reported, *P = .01 > .001, **P = .001 .0001, and ***P < .0001.