Increased ESAM1 and CDH5 expression on a subset of Crebbp^+/− endothelial cells. (A) Frequency of endothelial cells identified as CD45⁻Ter119⁻PECAM-1⁺ cells in the BM of wild-type (Wt) and Crebbp^+/− mice (n ≥ 7). (B) Representative histological sections of PECAM-1–stained vessels (shown in brown) in the BM of Wt and Crebbp^+/− mice (BX41 microscope; Olympus DP71 Digital Imaging System) at a magnification of 20×. (C) Data represent the average number of vessels ± SEM counted in the defined region 0.2 mm below the growth plate in the BM of Wt and Crebbp^+/− mice (n = 3-5). (D) Representative FACS profile and mean fluorescence intensities of ESAM1 expression on CD45⁻Ter119⁻PECAM-1⁺ BM cells (n = 6; P = .0005). (E) Representative FACS profile and mean fluorescence intensities of CDH5 expression on CD45⁻Ter119⁻PECAM-1⁺ BM cells (n = 4; P = .042).