p38 αβ^Y323F mice have reduced susceptibility to EAE. WT or p38αβ^Y323F mice were injected with MOG_35-55 in CFA. EAE clinical scores were determined between days 8 and 28 after injection, and each point represents the mean per animal ± SEM collected from 3 independent experiments (WT, n = 13; p38αβ^Y323F, n = 8).