Figure 3
Figure 3. Antigen and cytokines differently regulate expression of lineage-specifying transcription factors in IL-17–differentiating Vγ9Vδ2 T cells. RT-PCR of the expression of IL1βR, IL6R, TGFβR, IL23R, IL17, and RORC in naive (CD45RA+CD27+) human Vγ9Vδ2 T cells primed for various times (horizontal axes) with antigen, or left unprimed, in the presence or absence of cytokines. Data represent the mean values ± SD of 4 separate experiments, each performed with 5 different donors.

Antigen and cytokines differently regulate expression of lineage-specifying transcription factors in IL-17–differentiating Vγ9Vδ2 T cells. RT-PCR of the expression of IL1βR, IL6R, TGFβR, IL23R, IL17, and RORC in naive (CD45RA+CD27+) human Vγ9Vδ2 T cells primed for various times (horizontal axes) with antigen, or left unprimed, in the presence or absence of cytokines. Data represent the mean values ± SD of 4 separate experiments, each performed with 5 different donors.

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