Comparison of the time to anticoagulation correction with FFP treatment alone. Groups included patients treated before protocol initiation (n = 6; 25.4 ± 7 hours), during the protocol (n = 8; 8.9 ± 1.3 hours), and after protocol termination (n = 6; 11.2 ± 4.2 hours). An improvement in the time to correction was observed after protocol initiation and persisted after protocol termination (Reprinted, with permission from Boulis et al⁴⁰ ).