Figure 3
Arsenic targets critical pathways for the leukemia-initiating cells. Arsenic induces generation of ROS, perturbation of some signal pathways, and modulation of transcriptional factors. Arsenic also activates MEK1/ERK pathway, whereas combination of MEK1 inhibitor (MEKi, red filled circle) and arsenic results in synergistic antitumor effects.

Arsenic targets critical pathways for the leukemia-initiating cells. Arsenic induces generation of ROS, perturbation of some signal pathways, and modulation of transcriptional factors. Arsenic also activates MEK1/ERK pathway, whereas combination of MEK1 inhibitor (MEKi, red filled circle) and arsenic results in synergistic antitumor effects.

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