Significant effect of mouse or human down-regulated miRNAs on Myc targets. (A) GIs between Myc target genes and down-regulated miRNA genes in mouse irradiation-induced lymphomas. Peripheral yellow nodes represent down-regulated miRNA genes (as in Figure 2), whereas Myc targets are distributed as a circle around Myc (the interaction between Myc and Myc targets is not shown for clarity). A total of 72 Myc targets are potentially targeted by down-regulated miRNA genes, and only genes with more than or equal to 3 GI are shown. A complete list of these interactions is provided in the Supplemental data. (B) Similar analysis of the GI between MYC target genes and down-regulated miRNAs in BLs. Peripheral yellow nodes represent down-regulated miRNA genes (as in Figure 7), whereas MYC targets are distributed as a circle around MYC.