Genetic interactions between protein-coding genes and miRNAs in BL. (A) Heat map of significantly down-regulated miRNAs in BL compared with normal lymph nodes. (B) GSEA for down-regulated miRNAs targeting the MYC 3′-UTR. (C) Genetic interactions (GI) between up-regulated protein-coding genes and down-regulated miRNAs in BL. Only protein-coding genes with GI ≥ 6 are shown.