GIs between overexpressed genes and down-regulated miRNA genes. GIs are defined as the number of down-regulated miRNA genes that can potentially target specific sequences in all possible 3′-UTRs of the overexpressed gene indicated. (See supplemental Data for further details.) Myc is the overexpressed gene with the highest number of GIs in γ-irradiation-induced T-cell lymphomas. Thirteen of the 41 miRNA genes down-regulated in these tumors can potentially target the Myc 3′-UTR. Other genes potentially targeted by multiple miRNAs, such as Ncor2 (11 GI) and Kkbp3 (10 GI), are indicated in the figure. Only genes up-regulated in irradiation-induced lymphomas with more than or equal to 7 GI are represented.