Figure 1
IGFBP2-null mice have fewer HSCs than wild-type mice. The frequencies of BM Lin−Sca-1+Kit+ cells, ST-HSCs/MPPs as Lin−Sca-1+Kit+Flk2+CD34+ cells, and LT-HSCs as Lin−Sca-1+Kit+Flk2−CD34− cells in IGFBP2-null and WT male littermates (A; n = 8) and female littermates (B; n = 7-8) were compared. (C) The frequencies of BM progenitors CMP, GMP, MEP, and CLP in IGFBP2-null and WT mice (n = 4-5) were measured.

IGFBP2-null mice have fewer HSCs than wild-type mice. The frequencies of BM LinSca-1+Kit+ cells, ST-HSCs/MPPs as LinSca-1+Kit+Flk2+CD34+ cells, and LT-HSCs as LinSca-1+Kit+Flk2CD34 cells in IGFBP2-null and WT male littermates (A; n = 8) and female littermates (B; n = 7-8) were compared. (C) The frequencies of BM progenitors CMP, GMP, MEP, and CLP in IGFBP2-null and WT mice (n = 4-5) were measured.

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