Gene set enrichment analysis. Gene set enrichment analysis (GSEA) of gene expression in human MLL-rearranged AML (n = 23) compared with MLL–wild-type AML (n = 56; Ross et al²⁶ ) using 223 MLL fusion protein-bound genes. (Top) GSEA enrichment plot, ES = 0.4, P = .006. (Bottom) The top 60 genes showing increased expression in human MLL-rearranged leukemias.