ITGB7 silencing reverses CAM-DR to bortezomib and melphalan. (A-D) ITGB7^silenced and ITGB7^positive H929 (A-B) and MM1S (C-D) were incubated in 96 well-uncoated or FN-coated plates and cultured for 24 hours in the absence and presence of bortezomib (2.5nM; A,C) or melphalan (20mM; B,D). Annexin V staining was used to evaluate the cytotoxic effects of these agents under the indicated conditions. Shown are the mean ± SD of triplicates from 3 independent experiments (*P < .05; **P > .05).