Early administration of Hsp90 inhibitors suppresses type VII collagen–induced development of EBA clinical phenotype. (A) Vehicle or 17-DMAG (30 mg/kg) was administered 1 day before and 1 day after immunization of SJL mice with 60 μg of GST-mCVIIC. (B) Vehicle or TCBL-145 (3 mg/kg) was given daily for 14 days starting 1 day before immunization. Data are presented as the average clinical scores defined as the percentage of body surface area affected by skin lesions 6 weeks after immunization. Values are means ± SEM of ≥ 6 mice per group. *P < .05.