Pathways to diagnose AVWS according to the reason for testing. (A) Patients tested because of bleeding should also be evaluated for AVWS-associated disorders. If such a disorder is present, consider AVWS if VWF testing demonstrates quantitative or qualitative disorder of VWF. (B) Patients with known AVWS-associated disorders are suggested to undergo testing before surgery, and AVWS should be considered if VWF abnormalities are found.