DNA methylation distinguishes malignant from nonmalignant phenotypes in myeloma. (A) Hierarchical clustering of overall methylation in cell types can distinguish premalignant (green clade) and malignant phenotypes (red clade). (B) The number of probes differentially methylated in sequential steps of myeloma pathogenesis. Hypo indicates hypomethylated; hyper, hypermethylated at transition.