Alignment of serpins. Shown are the C-termini with the location of polymorphism Arg407Lys in α2AP. Residues in bold show identical (*), conserved (:) or semiconserved (.) substitutions. ATIII indicates antithrombin III; α1AT, α-1-antitrypsin; α1AC, α-1-antichymotrypsin; PAI1, plasminogen activator inhibitor 1; and PCI, protein C inhibitor. The alignment was made with ClustalW2.³⁰