Platelet response to rituximab. Boxplot of platelet counts (on log scale) over time in weeks for responders (gray) and nonresponders (white) from weeks 0 through 16. The first rituximab dose was administered in week 1. The broken horizontal line represents the primary outcome platelet count of 50 × 10⁹/L (50 000/mm³). The horizontal lines in each plot, from highest to lowest, represent the 90th, 75th, 50th (median), 25th, and 10th percentiles.