Figure 4
Hematopoietic differentiation potential of BM- and CB-derived iPSCs. (A) In coculture with OP9, blood-derived iPSCs generate a CD34+ population of cells with typical subsets including CD43+ hematopoietic progenitors, CD31+CD43− endothelial cells, and CD31−CD43− mesenchymal cells. The CD43+ population of hematopoietic cells consists of CD235a+CD41a+/− erythro-megakaryocytic progenitors and CD235a/CD41a−CD45+/− multipotent progenitors. The representative experiment shows hematopoietic subsets generated from the BM iPSC1 line. (B) Percentage of CD43+ hematopoietic cells generated from hESC H1, fibroblast (DF), and blood-derived (BM, CB) iPSC lines after 8 days of coculture with OP9.

Hematopoietic differentiation potential of BM- and CB-derived iPSCs. (A) In coculture with OP9, blood-derived iPSCs generate a CD34+ population of cells with typical subsets including CD43+ hematopoietic progenitors, CD31+CD43 endothelial cells, and CD31CD43 mesenchymal cells. The CD43+ population of hematopoietic cells consists of CD235a+CD41a+/− erythro-megakaryocytic progenitors and CD235a/CD41aCD45+/− multipotent progenitors. The representative experiment shows hematopoietic subsets generated from the BM iPSC1 line. (B) Percentage of CD43+ hematopoietic cells generated from hESC H1, fibroblast (DF), and blood-derived (BM, CB) iPSC lines after 8 days of coculture with OP9.

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