Characterization of the blood pressure of PRCP^gt/gt mice. (A) Hematoxylin and eosin staining of 6-month-old mouse kidney are shown from WT and PRCP^gt/gt mice. A thickened Bowman capsule (tubulization) is noted in the PRCP^gt/gt mice (compare thickness of Bowman capsule in WT vs gt/gt sections, black arrow). The images were photographed on an Olympus BH-2 microscope aperture 0.70 160/0.17 at 40×. (B) Carotid artery blood pressure measurement by a sensor for telemetry was performed on WT and PRCP^gt/gt mice (gt/gt; “Murine blood pressure measurements”). Hourly data were compiled from 4 days of measurement. Data are mean ± SEM of monitoring 9 WT, 8 PRCP^gt/gt, and 3 mitoTEMPO-treated PRCP^gt/gt (gt/gt+mitoTEMPO) mice. The dotted lines indicate an 8-hour period of the night or day cycle, respectively, used to analyze differences between groups. (C) Hourly data expressed in panel B are presented as an 8-hour period of the night or day cycle, respectively. One-way analysis of variance was used to determine differences among groups. *P < .05.