Figure 4
Figure 4. Targets of miR-155 and MYB become dysregulated in B-CLL. (A) Selected miR-155 target genes exhibiting differential expression between B-CLL (N = 12, patient codes are indicated on top of the heat maps) and normal B-cell samples (P < .05, t test). Genes were selected from the union of 6 lists of either predicted or experimentally validated target genes of miR-155 (“GSEA”). (B) Selected MYB target genes exhibiting differential expression between B-CLL (N = 12, patient codes are indicated on top of the heat maps) and normal B-cell samples (P < .05, t test). Genes were selected from 3 independent sources cataloguing the MYB target genes (“GSEA”).

Targets of miR-155 and MYB become dysregulated in B-CLL. (A) Selected miR-155 target genes exhibiting differential expression between B-CLL (N = 12, patient codes are indicated on top of the heat maps) and normal B-cell samples (P < .05, t test). Genes were selected from the union of 6 lists of either predicted or experimentally validated target genes of miR-155 (“GSEA”). (B) Selected MYB target genes exhibiting differential expression between B-CLL (N = 12, patient codes are indicated on top of the heat maps) and normal B-cell samples (P < .05, t test). Genes were selected from 3 independent sources cataloguing the MYB target genes (“GSEA”).

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