ARC19499 effect on bleeding time in a cynomolgus monkey model of acquired hemophilia A. (A) In vivo dosing scheme used to measure bleeding times in cynomolgus monkeys. (B) Effect of ARC19499 treatment on bleeding time of monkeys that responded to ARC19499. Group 1 received 1 dose of 1 mg/kg ARC19499, group 2 received 2 doses of 1 mg/kg ARC19499, and group 3 received 3 doses of 1 mg/kg ARC19499. Data for groups 1 and 2 represent the means ± SEM.