Representative profiles of the PB and LN samples of case 2. The results for case 2 were more complex than those for case 1. In both the PB and the LN samples of case 2, a log2 ratio imbalance was found. (A) In the PB sample, the arrowhead and dotted line indicate the majority of log2 ratios of gain and loss regions. Log2 ratios of the majority of loss regions were −0.82. The log2 ratio of chromosome 4 was −0.57. (B) In the LN sample, the arrowhead and dotted line indicate the majority of log2 ratios of gain and loss regions. Log2 ratios of the majority of loss regions were −0.55. The log2 ratio of chromosome 4 was −0.13. Chromosome 7 regions of PB and LN samples are magnified as Ci and Cii, respectively. (C) Chromosome 7 of the case 2 PB sample shows complex aberrations (i). This result also indicates a log2 ratio imbalance. Chromosome 7 of the case 2 LN sample shows more complex aberrations (ii). An arrow indicates a region (7q11.21-11q.23) without genomic aberration. Ci and Cii suggest that the genomic profiles of the PB and LN samples differ.