Electrophoresis agarose gel and chromatogram showing the NUP98/RARG rearrangement, and schematic representation of the NUP98/RARG fusion protein. (A) NUP98/RARG fusion. The reciprocal RARG/NUP98 fusion product was not detected. (B) Nucleotide and protein sequences surrounding the NUP98/RARG fusion region. The fusion was in-frame, so that the open reading frames of both genes in the fusion transcript were retained. The arrows indicate the break-point and fusion sites of the NUP98/RARG gene. (C) Schematic representation of the NUP98/RARG fusion proteins and its wild-type counterparts. The locations of the primers used for RT-PCR are indicated by horizontal arrows. GLFG repeats have been shown to be docking sites for transport receptors. P indicates patient cDNA (881bp); C1 and C2, PML/RARA patient's cDNA; M6, molecular weight; GLEBS, motif of nuclear export of poly(A)⁺ RNA and nuclear pore complex (NPC) structure; RBD, RNA-binding domain; DBD, In the abbreviations for Figure 2, “DBD, DNA-binding domain and distribution and arrows the joining site” has been rephrased as “DBD, DNA-binding domain. Arrows indicate the joining sites.” Please confirm or correct. DNA-binding domain. Arrows indicate the joining sites.