Hyperexhausted HIV-specific CD8⁺ T cells correlate with viremia. (A) Percentage of single inhibitory molecule expression on HIV-specific CD8⁺ T cells as a function of pVL (n = 52). (B) Percentage of PD-1⁺CD160⁺2B4⁺LAG-3⁻, PD-1⁺CD160⁻2B4⁺LAG-3⁻, and PD-1⁻CD160⁻2B4⁺LAG-3⁻ expression profiles on HIV-specific CD8⁺ T cells as a function of pVL (n = 47). Lines indicate correlations detected by Prism software Version 5.0c.