Delayed wound healing in Ki20227-treated mice. (A) Percentage wound closure of dorsal excisional wounds (n = 6). (B-C) Immunohistochemistry of CD31 in the healing edges at 7 days after wounding. Neovascularization is decreased in the wound area of Ki20227-treated mice compared with that of vehicle-treated mice. (D) Quantification in the capillary density in the healing edges 7 days after wounding (n = 6). Bar represents 50 μm. *P < .05. **P < .01.