Macrophages recruited into the wound tissues possess M2-polarized properties and express abundant MMPs. (A-H) FACS analysis for CD11b⁺ cells from unwounded tissues (blue lines) or dorsal excisional wounds at day 7 (red lines). Macrophages in wound tissues showed higher expression of Mrc1 (B), CD48 (D), and VEGFR1 (G) and lower expression of CD86 (C) and Tie-2 (E). (I-Q) Quantitative PCR analysis for CD11b⁺ cells from unwounded tissues (day 0) or dorsal excisional wounds at day 7 (n = 4). Macrophages in wound tissues showed higher expression of mmp2 (J), mmp9 (K), mmp13 (L), and csfr-1 (P) and lower expression of nos2 (H), il6 (I), vegfa (M), angpt1 (N), and cxcl-12 (O). *P < .05.