Figure 2
![Figure 2. Schematic representation of C/EBPα functional domain and mutations resulting in C/EBPα dysregulation. (A) Two transactivation domains (TAD1 and TAD2 [pink]) and the basic region and leucine zipper (bZip [blue]) are indicated. The mRNA translated from the ATG at nt1/aa1 encodes the wild-type 42-kDa C/EBPα, whereas the 30-kDa form is translated from ATG at nt358/aa120. (B) The 247dupC mutation results in a truncated N-terminal product with an altered amino acid sequence (green). The 30-kDa product that is generated from the alternative start codon lacks TAD1. (C) The 584_589dup mutation results in amino acid sequence His195_Pro196dup (orange) in TAD2. (D) The 914_916dup mutation results in amino acid sequence Gln305dup (orange) in bZip.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/117/19/10.1182_blood-2010-12-326322/4/zh89991170610002.jpeg?Expires=1724147533&Signature=UxAc7XE05Az8SNmlGtzaLUF4BHgWHTlP0KhSEIeEXJBdYbIdxczCuhjGbU3nWb3JVkVs7tOE7HaRTY1dUBO3IPjFd2gnoEzncvcDO5sqi9Bl3gx7ORjFAwDCyN0iGex9FBK9hf7ljVCDx~cJr2asCEBLGCJrMpsLfSqMAKQ4GWMJ2s3re8AoThed80ERDGZUSQMwa-YU0QQZrp026UpqP6WkLX63XQFuWvFDiAe-mBQnUVkbhC9H3A4noYA5uVTPMm9D2znWfxCUbarLtkm-RR3ZgjHPFnQzASnJa8T7o0A-7TwqVdFiSlNtyOwXLQBoJnQljFQ43zy0qZq855jU6A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Schematic representation of C/EBPα functional domain and mutations resulting in C/EBPα dysregulation. (A) Two transactivation domains (TAD1 and TAD2 [pink]) and the basic region and leucine zipper (bZip [blue]) are indicated. The mRNA translated from the ATG at nt1/aa1 encodes the wild-type 42-kDa C/EBPα, whereas the 30-kDa form is translated from ATG at nt358/aa120. (B) The 247dupC mutation results in a truncated N-terminal product with an altered amino acid sequence (green). The 30-kDa product that is generated from the alternative start codon lacks TAD1. (C) The 584_589dup mutation results in amino acid sequence His195_Pro196dup (orange) in TAD2. (D) The 914_916dup mutation results in amino acid sequence Gln305dup (orange) in bZip.
