Plasma concentration comparisons. (A) BLyS, (B) APRIL, (C) IL-6, and (D) IL-10 in rapid progressors (left panel), normal progressors (middle panel), and slow progressors (right panel). The same values are used for HIV-negative donors in the left, middle, and right graphs to show this group as a control. Plasma concentrations were compared with the Wilcoxon signed rank and Mann-Whitney U tests for pairwise comparisons of different phases of infection within each group and between the study groups, respectively. *P < .05; **P < .001; ***P < .0001. PI, postinfection; ART, antiretroviral treatment. Values greater than the mean plus 3 times standard deviation were removed from the analysis.