Figure 2
Figure 2. KO of myeloid CSN5 leads to prevention of LPS-induced pulmonary inflammation in CSN5fl/flLyzsM-Cre mice. (A) Immunohistologic staining of lung sections of CSN5fl/fl and CSN5fl/flLyzsM-Cre mice at 48 hours after CLP ligation. Representative antimyeloperoxidase-stained sections (original magnification ×10) of lung are shown 48 hours after the CLP ligation. The induction of TNF-α (B) and NO (C) production in the sera and BAL after CLP ligation was determined by ELISA. (B-C) Data are presented as mean ± SEM. n = 10; **P < .01.

KO of myeloid CSN5 leads to prevention of LPS-induced pulmonary inflammation in CSN5fl/flLyzsM-Cre mice. (A) Immunohistologic staining of lung sections of CSN5fl/fl and CSN5fl/flLyzsM-Cre mice at 48 hours after CLP ligation. Representative antimyeloperoxidase-stained sections (original magnification ×10) of lung are shown 48 hours after the CLP ligation. The induction of TNF-α (B) and NO (C) production in the sera and BAL after CLP ligation was determined by ELISA. (B-C) Data are presented as mean ± SEM. n = 10; **P < .01.

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