FVL heterozygosity ameliorates diabetic nephropathy in diabetic patients. Average albuminuria in diabetic patients with either type 1 (DMT1; A) or type 2 (DMT2; B) diabetes mellitus stratified according to the genetic FVL or PAI-1 4G/5G polymorphisms. Average albuminuria was lower in patients carrying the FVL mutation (FVL pos) than in patients not carrying the FVL mutation (FVL neg), but did not differ in patients stratified according to the PAI-1 polymorphism. Means ± SEM are shown; *P < .05; **P < .01 (ANOVA).