Torin-1 and hydrocortisone reciprocally mimic the immunomodulatory effects of rapamycin (Rap) and dexamethasone (Dex). Human monocytes were pretreated with the indicated amounts of (A-B) Dex or (C-D) hydrocortisone (HC) and then incubated with (A-B) Torin-1 or (C-D) Rap and finally stimulated with 100 ng/mL LPS. (A,C) IL-12p40 and (B,D) IL-10 were determined in the supernatants after 20 hours (mean ± SEM; n = 3). *P < .05. n.s. indicates not significant.