Figure 2
Reduced numbers of lymph node αβ T cells but not γδT cells in FU-Lcktg mice. (A) FACS dot plots showing proportions of αβ and γδ T cells in lymph nodes from 7-week-old WT, Lck−/−, Lcktg/Lck−/−, and FU-Lcktg/Lck−/− mice. Values within dot plots represent the percentage of lymphocyte-gated αβ and γδTCR-positive cells. (B) Distribution of CD4+ and CD8+ T cells in lymph nodes. Values represent proportions of αβTCR+ cells within CD4+ and CD8+ gates. Histograms showing CD44 expression on gated lymph node αβTCR+CD4+ T cells (C) or CD8+ T cells (D) from WT, Lck−/−, Lcktg/Lck−/−, and FU-Lcktg/Lck−/− mice. Values in histograms represent percentages of cells falling within the illustrated CD44 “high” gate. In all cases, data are representative of at least 11 mice of each genotype.

Reduced numbers of lymph node αβ T cells but not γδT cells in FU-Lcktg mice. (A) FACS dot plots showing proportions of αβ and γδ T cells in lymph nodes from 7-week-old WT, Lck−/−, Lcktg/Lck−/−, and FU-Lcktg/Lck−/− mice. Values within dot plots represent the percentage of lymphocyte-gated αβ and γδTCR-positive cells. (B) Distribution of CD4+ and CD8+ T cells in lymph nodes. Values represent proportions of αβTCR+ cells within CD4+ and CD8+ gates. Histograms showing CD44 expression on gated lymph node αβTCR+CD4+ T cells (C) or CD8+ T cells (D) from WT, Lck−/−, Lcktg/Lck−/−, and FU-Lcktg/Lck−/− mice. Values in histograms represent percentages of cells falling within the illustrated CD44 “high” gate. In all cases, data are representative of at least 11 mice of each genotype.

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