Figure 5
Figure 5. Rejection of a third-party allogeneic skin graft in the presence of rsTreg. [BALB/c × C57BL/6]F1 recipient mice were lethally irradiated and then grafted with 3 × 106 CD3ε−/− BM and 3 × 106 allogeneic Ly5.1+ C57BL/6 T cells with 3 × 106 rsTreg. At day 30, tail-skin grafts from C57BL/6 (n = 10; solid line) and C3H (n = 5; dashed line) mice were transplanted onto the lateral thoracic wall of reconstituted mice. Skin-graft survival curves are shown for each group of 1 representative experiment.

Rejection of a third-party allogeneic skin graft in the presence of rsTreg. [BALB/c × C57BL/6]F1 recipient mice were lethally irradiated and then grafted with 3 × 106 CD3ε−/− BM and 3 × 106 allogeneic Ly5.1+ C57BL/6 T cells with 3 × 106 rsTreg. At day 30, tail-skin grafts from C57BL/6 (n = 10; solid line) and C3H (n = 5; dashed line) mice were transplanted onto the lateral thoracic wall of reconstituted mice. Skin-graft survival curves are shown for each group of 1 representative experiment.

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