Figure 1
Figure 1. rsTreg prevent GVHD in C57BL/6→BALB/c × C57BL/6]F1 BM transplantation. [BALB/c × C57BL/6]F1 recipient mice were lethally irradiated and then grafted with 3 × 106 CD3ε−/− BM cells (control group, BM only □; n = 8) plus 3 × 106 allogeneic Ly5.1+ C57BL/6 T cells alone (Tallo ▵; n = 8) or with 3 × 106 specific rsTreg (Tallo+rsTreg ▴; n = 7). (A) Kaplan-Meier survival curves and (B) mean body weight curves were established for each group at different time points. Each symbol represents the mean value and bars are the SD. *P < .05 for BM vs Tallo at day 20 and for BM vs Tallo and BM only vs Tallo+rsTreg at days 29, 41, and 65.

rsTreg prevent GVHD in C57BL/6→BALB/c × C57BL/6]F1 BM transplantation. [BALB/c × C57BL/6]F1 recipient mice were lethally irradiated and then grafted with 3 × 106 CD3ε−/− BM cells (control group, BM only □; n = 8) plus 3 × 106 allogeneic Ly5.1+ C57BL/6 T cells alone (Tallo ▵; n = 8) or with 3 × 106 specific rsTreg (Tallo+rsTreg ▴; n = 7). (A) Kaplan-Meier survival curves and (B) mean body weight curves were established for each group at different time points. Each symbol represents the mean value and bars are the SD. *P < .05 for BM vs Tallo at day 20 and for BM vs Tallo and BM only vs Tallo+rsTreg at days 29, 41, and 65.

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