Dasatinib-treated mice exhibit a normal platelet life span. Control mice (solid line) and dasatinib-treated (5 mg/kg/d) mice (dashed line) were intravenously injected with biotin-NHS on day 0 and the percentage of biotinylated platelets was determined at the indicated times by flow cytometry (A). Relating this value to the determined platelet count yielded the number of nonbiotinylated platelets (B). Error bars represent SEM; **P < .01; n = 5 for each time point.