Coexpression of ectopic c-MYC does not cooperate in Top-NOTCH tumor formation or prevent tumor regression. (A) Schematic of the tumor formation protocol. (B) Diagram of retroviral constructs. (C) Death curve of mice reconstituted with Top-NOTCH bone marrow infected with MIT-c-MYC (left panel) and MIT-GFP (right panel). (D) Top-NOTCH/MIT-c-MYC mouse before and after treatment with Dox. *Reduction of lymph nodes.