A TPO mimetic is effective in ameliorating HDACI-induced TCP. Cohorts of C57BL/6 mice were treated with (A) daily IP panobinostat (Pan) 10 mg/kg or (B) daily IP romidepsin (Romi) 1 mg/kg, with vehicle IP daily, AMP-4 20 μg/kg on days 3 and 6, or the combination of HDACI and AMP-4. At the indicated time points, platelet counts were assessed from 3 mice in each group. AMP-4 was able to ameliorate HDACI-induced TCP. Error bars represent SEM. Platelet counts of mice treated with HDACI alone and HDACI in combination with AMP-4 were compared using a 2-tailed unpaired t test.