Figure 6
![Figure 6. Pak1 and RAC1 inhibition phenocopy the effects of HDACIs on pMLC levels. (A) Western blot performed on Meg-01 cells treated for 24 hours with 10μM of the PAK1 inhibitor WR PAK18 showing an increase in pMLC levels. (B) Western blot performed on Meg-01 cells transduced with a constitutively activate (CA Rac1) or dominant-negative (DN Rac1) Rac1, showing a decrease and increase, respectively, in pMLC levels compared with empty vector (murine stem cell virus [MSCV]) alone.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/117/13/10.1182_blood-2010-11-318055/4/zh89991168620006.jpeg?Expires=1724240193&Signature=S2HK3WZyCx6rYR7FPgjC93yRVnF4HS~bJsg7uywlDh1okClTO1qXSsuA6LlNFBy3~qlXnkRhDLqZfELoPPgmLiXd8mJVrFMMrk4IyjequtN1f-24wmIRyf6WBLIRSK-Vmmre5R0o97JWjBiFRYNO6hB5vLxVCpYNf~LygUWl48tU7U7FlA-ccZCRme7ZLumaT7JPayyytW3DXRyBrbus3YwroUrDaTo-P6dWfgtZYsnoMlOjGbGhFKP-chQ8JZdvU-d-nj7pfeWvnE9CDSwa8rUPqTXCjW3E9C2k3e5O6Cu0ubpZlrAywt5tW6tSXkHb92vbcU4uzhjuzXdxNng-iQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Pak1 and RAC1 inhibition phenocopy the effects of HDACIs on pMLC levels. (A) Western blot performed on Meg-01 cells treated for 24 hours with 10μM of the PAK1 inhibitor WR PAK18 showing an increase in pMLC levels. (B) Western blot performed on Meg-01 cells transduced with a constitutively activate (CA Rac1) or dominant-negative (DN Rac1) Rac1, showing a decrease and increase, respectively, in pMLC levels compared with empty vector (murine stem cell virus [MSCV]) alone.
