Stress granulopoiesis in G193X Elane mice. (A) Wild-type or G193X Elane mice on a 129/SvJ (A) (n = 9-10) or C57BL/6 (B) (n = 3-4) background were treated with a single intraperitoneal injection of 5-FU (200 mg/kg) on day 0. The absolute neutrophil count was determined at the indicated time points. (C) Wild-type or G193X Elane mice on a C57Bl/6 background (Ly5.2) were mixed with an equal number of congenic wild-type bone marrow cells (Ly5.1/5.2) and injected into irradiated congenic (Ly5.1) mice. The percentage of Ly5.2 cells in the indicated lineage is shown at 16 weeks after transplantation (n = 4-5). Data represent the means ± SEM. *P < .05.