Pedigree of a patient with WM with a P-7–specific IgM paraprotein carrying the pP-7. (A) The pedigree shows the family of a 50-year-old man with WM (II.1), having a P-7–reactive paraprotein and carrying the hyperphosphorylated state of this protein. The pattern of a pP-7 carrier state in this family is consistent with an autosomal dominant trait. (B) Immunostaining of lysate bands derived from whole peripheral blood lysates from family members carrying wild-type (I.3; I.4; II.2; II.3; II.4; III.2; III.3; III.4; III.5; III.6) and pP-7 (I.1; I.2; II.1; II.5; III.1) after IEF. The numbers indicate family members in different generations.