Effect of aged platelets transfusion on pulmonary coagulation and fibrinolysis. Concentrations of TATc, PAA, PAI-1, and FDP in the BALF of animals receiving saline or LPS as “first hit” and subsequently infusion of saline (control), fresh PLTs (day 0), or aged PLTs (day 5). Data are presented as mean ± SEM. Aged PLTs products activate lung coagulation and decrease fibrinolysis in LPS-primed rats as shown by an increase in TATc level in the BALF and decrease of PAA% and increase of PAI-1 levels in the BALF, respectively. *P < .05, **P < .01, ***P < .001.