Gene expression profile analysis of 52 DLBCL. (A) Gene plots of the gene sets related to p16ink4a/pRb/E2F pathway (top left), containing E2F binding site (top right), related to the host response (bottom left), and related to the GCB/ABC signature (bottom right) that were differentially expressed between DLBCL with or without 9p21 locus deletion. These plots represent the influence of individual genes of each pathway to the differential expression in 2 groups of samples. For each gene probe set (x-axis), a bar and a reference line are shown. The reference line shows the expected height of the bar under the null hypothesis that the gene is not statistically associated with a DLBCL subgroup. The height of the bar indicates the strength of the association of each probe set with the DLBCL subgroup. The horizontal lines in each bar represent how many standard deviations the gene expression exceeds the hypothesis that there would be no difference between groups (z-score). Genes with higher expression in DLBCL with 9p21 locus deletion are shown in green, and those in DLBCL without 9p21 locus deletions are shown in yellow. (B) Assemblage of genes expressed differentially in DLCBL with CDKN2A deletion into molecular networks. Network 1 represents genes with decreased expression; Network 2, genes with increased expression. Adjusted P value (threshold < .10) and log of the fold change expression are indicated for each gene tested in array experiments.