Differentiation potential of wt and Hhex^−/− CD45⁺ cells. The ability to produce lymphoid and myeloid progeny from wt and Hhex^−/− CD45⁺ cells remains intact. (A) The frequency of CD45⁺B220⁺ B cells as determined by flow cytometry, from wt Jet and Hhex^−/− cocultures on days 6 to 9. A significant change in B-cell frequency was observed on day 6 in the Hhex^−/− cocultures but not on subsequent days (P < .05, 2-tailed t test). (B) The frequency of CD45⁺CD19⁺ B cells from wt Jet and Hhex^−/− cocultures. (C) The frequency of CD45⁺CD11b⁺ cells from wt Jet and Hhex^−/− cocultures. Error bars represent SD.