Distribution of small RNAs in normal and malignant B cells. (A) Expression of small RNAs, including miRNAs, tRNA, piRNA, snRNA, rRNA, snoRNA, and tiRNA in each sample are shown more than a 2-fold range. Samples are listed in the same order as in Table 1. (B) Expression of miRNAs measured by sequencing across 2 biologic replicates for naive, germinal center, memory, and plasma B cells. The P values were computed using a correlation test against the null hypothesis that the data were not correlated; P < 10−6 in all 4 cases. (C) Relative expression of miRNAs differentially expressed in the naive to germinal center B-cell transition as measured by real-time PCR and sequencing. (D) Relative expression of miRNAs differentially expressed in the germinal center B-cell to plasma transition as measured by real-time PCR and sequencing. (E) Relative expression of miRNAs differentially expressed in the germinal center B to memory B-cell transition as measured by real-time PCR and sequencing.
