Serum titers of AST, ALT and soluble IL-2Rα in transgenic and control mice lacking or harboring B-cell lymphomas. (A-B) The AST (A) and ALT (B) assays were performed on serum samples from tumor-free control mice and the RzCD19Cre, Rz, CD19Cre and WT mice with or without B-cell lymphomas or other tumors. (C) ELISA analysis was performed to determine the sIL-2Rα concentration in serum samples from tumor-free control mice and the RzCD19Cre, Rz, CD19Cre, and WT mice with or without B-cell lymphomas or other tumors. (D) Concentration of soluble IL-2Rα in sera from transgenic (MxCre/CN2-29 or CN2-29) mice with or without B-cell lymphomas (*P < .05).