MicroRNAs are aberrantly expressed in SzS. (A) Unsupervised cluster analysis of microRNA expression data (miRBase v. 9.0) for purified lymphocyte subsets (n = 18), B-cell lymphoma samples (n = 98), hematologic cell lines (n = 42), and Sézary Syndrome (SzS) samples (n = 21). (B) Unsupervised cluster analysis of control CD4⁺ T cells (n = 6) and SzS samples (n = 21) using extended human probe set (miRBase v. 10.1; n = 655). Expression levels of (C) miR-150, (D) miR-223, (E) miR-181a, (F) miR-191, (G) miR-15a, (H) miR-16, (I) miR-24, (J) miR-145, and (K) miR-518a-3p in SzS samples (n = 17) and CD4⁺ T-cell (n = 7) and CD3⁺ T-cell (n = 6) controls measured by qRT-PCR. P values relate to SzS versus control CD4⁺ T cells (Mann-Whitney independent t test). Data shown as box-whisker plots.