In situ laser injury studies in the murine HIT model. (A) Shown are cumulative information for platelets (green) and monocytes (pink) at a site of induced injury for ≥ 10 injuries per condition within the arterioles and venules and pre- and post-KKO as indicated. (B) Same as in panel A but still from video at 4 minutes from an arteriole injury showing the accumulation of CD115⁺-monocytes and/or microparticles at the upstream end of a growing thrombus. Platelets appear green, monocytes pink, and the overlap white. The yellow arrow denotes the direction of blood flow.