Forodesine in presence of dGuo inhibited the global RNA and protein synthesis in CLL cells, while MSCs augmented the macromolecule syntheses. (A-B) CLL cells (n = 10) were incubated with or without 2μM forodesine and 20μM dGuo in suspension or on MSCs for 48 hours. The global RNA synthesis was measured by uridine incorporation assay in treated and untreated time-matched controls (A), and the global protein synthesis was measured by leucine incorporation assay in treated and untreated (n = 5) time-matched controls (B). C indicates CLL; F, forodesine plus dGuo; M, M210B4; and N, NKtert.