Kaplan-Meier curves for TTFT and OS in 316 CLLs. Patients are stratified in high and low Ang2 subsets based on Ang2 levels (cutoff, 2459 pg/mL). High Ang2 CLLs display significantly shorter TTFT (A) and OS (B) compared with low Ang2 CLLs (P < .001 and P = .002, respectively; log-rank test).